W. Lesiński, K. Mnich, W.R. Rudnicki. Prediction of alternative Drug Induced Liver Injury classifications using molecular descriptors, gene expression perturbation, and toxicology reportsFrontiers in Genetics 12:661075 (2021), DOI: 10.3389/fgene.2021.661075 (100 pkt. MNiSzW) Motivation: Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI, based on the chemical properties of substances and experiments performed on cell lines, would bring a significant reduction in the…
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New paper in Biology Direct!
W. Lesiński, K. Mnich, A. Kitlas Golińska, W.R. Rudnicki. Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction. Biology Direct 16:2 (2021). DOI: 0.1186/s13062-020-00286-z (100 pkt. MNiSzW) Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined…